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Infusion of low dose dopamine did not reduce renal failure in at risk patients in the intensive care unit

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QUESTION: Does low dose dopamine decrease the risk of renal failure in at risk patients in the intensive care unit (ICU)?


Randomised (allocation concealed), blinded (patients, clinicians, outcome assessors, data analysts), controlled trial with follow up to defined study events.


23 ICUs in Australia, New Zealand, and Hong Kong.


328 patients who had central venous catheters, ≥2 pathophysiological changes of the systemic inflammatory response syndrome (SIRS) over a 24 hour period, and ≥1 indicator of early renal dysfunction (mean urine output <0.5 ml/kg/h over ≥4 h, serum creatinine concentration >150 μmol/l with no premorbid renal dysfunction, increase in serum creatinine concentration of >80 μmol/l in <24 h without creatine kinase >5000 IU/l or myoglobin in the urine). Exclusion criteria were age <18 years, episode of acute renal failure …

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  • * Information provided by author.

  • Sources of funding: Australian and New Zealand Intensive Care Society and the Austin and Repatriation Anaesthesia and Intensive Care Trust Fund.

  • For correspondence: Mrs A Burger, ANZICS House, 233 Rathdowne Street, Carlton, Victoria 3503, Australia. Fax +61 3 9639 4717.