Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
P S Aisen
Dr P S Aisen, University of California, San Diego, CA, USA; firstname.lastname@example.org
Do high-dose vitamin B supplements reduce rate of cognitive decline in patients with Alzheimer disease (AD)?
randomised placebo controlled trial. Clinicaltrials.gov NCT00056225.
blinded (patients, caregivers, clinicians, and psychometrists).
every 3 months up to 18 months.
40 centres in the USA.
409 patients >50 years of age (mean age 76 y, 56% women), who had probable AD, scored 14–26 on the Mini-Mental State Examination (MMSE), and were medically stable. Exclusion criteria were vitamin B12 concentrations <129 pmol/l (175 pg/ml), folate concentrations <9.5 nmol/l (4.2 ng/ml), renal insufficiency (serum creatinine ⩾176.8 µmol/l [2.0 …
Source of funding: National Institute on Aging and National Institutes of Health.