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High-dose vitamin B supplements did not slow cognitive decline in patients with mild-to-moderate Alzheimer disease

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P S Aisen

Dr P S Aisen, University of California, San Diego, CA, USA;


Do high-dose vitamin B supplements reduce rate of cognitive decline in patients with Alzheimer disease (AD)?



randomised placebo controlled trial. NCT00056225.




blinded (patients, caregivers, clinicians, and psychometrists).

Follow-up period:

every 3 months up to 18 months.


40 centres in the USA.


409 patients >50 years of age (mean age 76 y, 56% women), who had probable AD, scored 14–26 on the Mini-Mental State Examination (MMSE), and were medically stable. Exclusion criteria were vitamin B12 concentrations <129 pmol/l (175 pg/ml), folate concentrations <9.5 nmol/l (4.2 ng/ml), renal insufficiency (serum creatinine ⩾176.8 µmol/l [2.0 …

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  • Source of funding: National Institute on Aging and National Institutes of Health.