An intramolecular Heck reaction (90 → 91) serves as the key step in the total synthesis of the
titled compounds. The synthetic route is based on utilizing the Wieland−Miescher ketone (5…

Bruton’s tyrosine kinase (Btk) is a nonreceptor cytoplasmic tyrosine kinase involved in B-cell
and myeloid cell activation, downstream of B-cell and Fcγ receptors, respectively. …

Purpose. We evaluated the Macroflux® microprojection array patch technology as a novel
system for intracutaneous delivery of protein antigens. Methods. Macroflux® microprojection …

Taxol (1) is a clinically useful antitumor agent. First approved for the treatment ofovarian
cancer. it is currently being evaluated for efficacy against a broader range of tumors.['l The …

Rhodium (II) acetate catalyzed decomposition of vinyldiazomethanes in the presence of iV-(alkoxycarbonyDpyrroles
led to the synthesis of 8-azabicyclo [3.2. 1] octa-2, 6-dienes. The …

Bruton's tyrosine kinase (Btk) is a therapeutic target for rheumatoid arthritis, but the cellular
and molecular mechanisms by which Btk mediates inflammation are poorly understood. Here …

To investigate the relation of aluminum and silicon in drinking water to risk of Alzheimer's
disease, we carried out a case-control study in eight regions of England and Wales. Subjects …

Background and Purpose— The characteristics of intracerebral hemorrhage (ICH) may vary
by ICH location because of differences in the distribution of underlying cerebral small vessel …

The Bruton’s tyrosine kinase (Btk) inhibitor ibrutinib has shown impressive clinical efficacy
in a range of B-cell malignancies. However, acquired resistance has emerged, and second …

Starting from the oxindole 2a identified through a high-throughput screening campaign, a
series of Na V 1.7 blockers were developed. Following the elimination of undesirable structural …