Original researchBenefits of soy isoflavone therapeutic regimen on menopausal symptoms☆
Section snippets
Materials and methods
This study was a randomized, double-blind, placebo-controlled trial designed to investigate the extent to which isoflavone 100 mg per day (Eugenbio Co. Ltda, Seoul, South Korea) decreased menopausal symptoms as well as affected cardiovascular risk and endogenous hormone levels. Subjects for the present study consisted of women aged 45–55 years who attended screening and baseline visits and were subsequently enrolled in the isoflavone program in the Division of Endocrinological Gynecology and
Results
The epidemiologic and clinical characteristics of age, race, education, and social status, use of nicotine and dietary and nutritional habits, and clinical problems were similar in both groups (Table 1). Subjects reported no consumption of alcohol. All participants exercised less than three times per week.
To evaluate the menopausal symptoms, the menopausal Kupperman index questionnaire was applied. In the first visit, symptoms were similar between placebo and isoflavone groups (Table 2).
Discussion
Some critics might question the optimal daily dose required to recognize a clinical response. Some authors cited a per capita estimated intake of 50–200 mg of iosflavone daily in an Asian diet.23, 24 Also, others may consider the length of time on the soy isoflavones as too short to elicit a clinical response.16 However, it has been determined that genistein and diadzein plasma concentrations peak 6–8 hours after ingestion.25 These data endorse our choice of 33.3 mg 8/8 hours per day as
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We would like to thank Dr. Mercedes C. Panizzi; Marcos G. Mandarino and Dr. Akio Kikuchi (Brazilian Research Institute of Agriculture [EMBRAPA], Brasilia, Brazil); Dr. Tai W. Kwon and Dr. Sung R. Kim (Korea Food Research Institute, Seoul, Korea); Dr. Dong K. Yim (Food Technology of Campinas-[ITAL]), Campinas, Brazil; and Dr. Myoung K. Park (Life Science Research Center of Eugenbio Inc., Seoul, Korea) for their priceless efforts and cooperation in our study.