Elsevier

Neurotoxicology and Teratology

Volume 17, Issue 4, July–August 1995, Pages 445-462
Neurotoxicology and Teratology

Article
Maternal risk factors in fetal alcohol syndrome: Provocative and permissive influences

https://doi.org/10.1016/0892-0362(95)98055-6Get rights and content

Abstract

We present an hypothesis integrating epidemiological, clinical case, and basic biomedical research to explain why only relatively few women who drink alcohol during pregnancy give birth to children with alcohol-related birth defects (ARBDs), in particular, Fetal Alcohol Syndrome (FAS). We argue that specific sociobehavioral risk factors, e.g., low socioeconomic status, are permissive for FAS in that they provide the context for increased vulnerability. We illustrate how these permissive factors are related to biological factors, e.g., decreased antioxidant status, which in conjunction with alcohol, provoke FAS/ARBDs in vulnerable fetuses. We propose an integrative heuristic model hypothesizing that these permissive and provocative factors increase the likelihood of FAS/ARBDs because they potentiate two related mechanisms of alcohol-induced teratogenesis, specifically, maternal/fetal hypoxia and free radical formation.

References (327)

  • M.W. Church et al.

    Interactive effects of prenatal alcohol and cocaine exposures postnatal mortality, development and behavior in the Long-Evans rat

    Neurotoxicol. Teratol.

    (1991)
  • S.K. Clarren et al.

    Fetal alcohol syndrome: A new primate model for binge drinking and its relevance to human ethanol teratogenesis

    J. Pediatrics

    (1982)
  • C.D. Coles et al.

    Effects of prenatal alcohol exposure at school age. I. Physical and cognitive development

    Neurotoxicol. Teratol.

    (1991)
  • C.D. Coles et al.

    Effects of cocaine and alcohol use in pregnancy as neonatal growth and neurobehavioral status

    Neurotoxicol. Teratol.

    (1992)
  • M.A. Crawford et al.

    Essential fatty acid requirements in pregnancy and lactation with special reference to brain development

    Prog. Lipid Res.

    (1981)
  • R.R. Crichton

    Iron metabolism and oxygen toxicity

    Bioelectrochem. Bioenerget.

    (1987)
  • S. Dally et al.

    High blood lead level in alcoholics: Wine vs. beer

    Drug Alc. Depend.

    (1989)
  • R. Dargel

    Lipid peroxidation — A common pathogenetic mechanism?

    Exp. Toxic. Pathol.

    (1992)
  • N.L. Day et al.

    The effect of prenatal tobacco and marijuana use on offspring growth from birth through 3 years of age

    Neurotoxicol. Teratol.

    (1992)
  • H. De Groot et al.

    Hypoxia, reactive oxygen, and cell injury

    Free Radical Biol. Med.

    (1989)
  • N.H. Diemer et al.

    Glutamate receptor reception and ischemic nerve cell damage: Evidence for involvement of excitotoxic mechanisms

    Prog. Brain Res.

    (1993)
  • C.D. Driscoll et al.

    Prenatal alcohol exposure: Comparability of effects in humans and animal models

    Neurotoxicol. Teratol.

    (1990)
  • R.W. Egan et al.

    Oxidation reactions by prostaglandin cyclooxygenase-hydroperoxidase

    J. Biol. Chem.

    (1981)
  • C.B. Ernhart

    A critical review of low-level prenatal lead exposure in the human: 1. Effects on the fetus and newborn

    Reproduct. Toxicol.

    (1992)
  • C.B. Ernhart et al.

    Fetal lead exposure: Antenatal factors

    Environ. Res.

    (1985)
  • H.J. Forman et al.

    Superoxide radical and hydrogen peroxide in mitochondria

  • H.E. Fox et al.

    Maternal ethanol ingestion and the occurrence of human fetal breathing movements

    Am. J. Obstet. Gynecol.

    (1978)
  • P.A. Fried et al.

    12- and 24-month neurobehavioral followings of children prenatally exposed to marijuana, cigarettes and alcohol

    Neurotoxicol. Teratol.

    (1988)
  • K. Fukuzawa et al.

    Location and dynamics of α-tocopherol in model phospholipid membranes with different charges

    Chem. Phys. Lipid.

    (1992)
  • S.H. Gilani et al.

    Development of the chick embryo following PGE1 treatment

    Prostaglandins Med.

    (1981)
  • E.L. Abel

    Characteristics of mothers of fetal alcohol syndrome children

    Neurobehav. Toxicol. Teratol.

    (1982)
  • E.L. Abel

    Consumption of alcohol during pregnancy: A review of effects on growth and development of offspring

    Human Biol.

    (1982)
  • E.L. Abel

    Smoking and pregnancy

    J. Psychoactive Drugs

    (1984)
  • E.L. Abel

    Fetal Alcohol Syndrome and fetal alcohol effects

    (1984)
  • E.L. Abel

    Effects of prenatal exposure to cannabinoids

  • E.L. Abel

    Alcohol enhancement of marihuana-induced fetotoxicity

    Teratology

    (1985)
  • E.L. Abel

    Behavioral teratogenesis and behavioral mutagenesis. A primer in abnormal development

    (1989)
  • E.L. Abel

    Fetal Alcohol Syndrome

    (1990)
  • Abel, E. L. An update on incidence of FAS: FAS is not an equal opportunity birth defect. Neurobehav. Toxicol. (in...
  • Abel, E. L.; Hannigan, J. H. J-shaped relationship between drinking during pregnancy and birth weight: Reanalysis of...
  • Abel, E. L.; Kruger, M. L. Hon v. Stroh Brewery Co.: What do we mean by “moderate” and “heavy” drinking...
  • E.L. Abel et al.

    Ratings of fetal alcohol syndrome facial features by medical providers and biomedical scientists

    Alc. Clin. Exp. Res.

    (1993)
  • E.L. Abel et al.

    A revised conservative estimate of the incidence of FAS and its economic impact

    Alc. Clin. Exp. Res.

    (1991)
  • F.W. Alexander et al.

    Blood lead levels during pregnancy

    Int. Arch. Environ. Hlth.

    (1981)
  • G.M. Al-Hackim

    Teratogenicity of caffeine: A review

    Eur. J. Obstet. Gyn. Rep. Biol.

    (1989)
  • H.L. Altshuler et al.

    A subhuman primate model for fetal alcohol syndrome research

    Neurobehav. Toxicol. Teratol.

    (1981)
  • B.M. Altura et al.

    Alcohol produces spasms of human umbilical blood vessels: Relationship to fetal alcohol syndrome (FAS)

    Eur. J. Pharmacol.

    (1983)
  • H. Amaro et al.

    Violence during pregnancy and substance abuse

    Am. J. Public Health

    (1990)
  • Folate deficiency parenteral caffeine, and cytogenic damage in mice

    Nutri. Rev.

    (1991)
  • J.E. Archer et al.

    Prenatal psychological stress and offspring behavior in rats and mice

    Devel. Psychobiol.

    (1971)
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