RCTs of interventions for chronic fatigue syndrome*

InterventionsNumber of RCTsNumber of patientsOverall effect: number of studies showing improvement or no difference
*RCTs = randomised controlled trials; GET = graded exercise therapy; CBT = cognitive behavioural therapy. Intervention duration ranged from 2 weeks to 1 year (mean 16 wks); follow up ranged from 2 weeks to 5 years.
Behavioural88836 improvement; 2 no difference
    GET33503 improvement
    CBT55333 improvement; 2 no difference
Immunological94404 improvement; 5 no difference
Pharmacological128962 improvement; 10 no difference
Supplements51742 improvement; 3 no difference
Complementary or alternative2841 improvement; 1 no difference