At a mean 8 years | |||||
Outcomes | Vitamin E | Vitamin C | Placebo | Adjusted RRR (95% CI)‡ | NNT |
Major cardiovascular events | 8.4% | 8.6% | 1.0% (−10 to 11) | NS |
Adjusted RRI (CI)‡ | NNH | ||||
Major cardiovascular events† | 8.5% | 8.5% | 1.0% (−10 to 12) | NS | |
All-cause mortality | 11% | 11% | 6.6% (−3 to 17) | NS | |
12% | 11% | 6.6% (−3 to 17) | NS |
*Abbreviations defined in glossary. RRR, RRI, NNT, NNH, and CI calculated from data in article.
†Composite outcome of non-fatal myocardial infarction, non-fatal stroke, and CV death.
‡Adjusted for age, Physicians’ Health study cohort, group assignment, and other randomised interventions (β-carotene and multivitamin).