TY - JOUR T1 - Review: insufficient evidence exists on the effectiveness of proton pump inhibitors for adults with prolonged non-specific cough associated with gastro-oesophageal reflux JF - Evidence Based Nursing JO - Evid Based Nurs SP - 73 LP - 73 DO - 10.1136/ebn.9.3.73 VL - 9 IS - 3 A2 - , Y1 - 2006/07/01 UR - http://ebn.bmj.com/content/9/3/73.abstract N2 - Chang AB, Lasserson TJ, Gaffney J, et al. Gastro-oesophageal reflux treatment for prolonged non-specific cough in children and adults. Cochrane Database Syst Rev 2005;(2):CD004823.Chang AB, Lasserson TJ, Kiljander TO, et al. Systematic review and meta-analysis of randomised controlled trials of gastro-oesophageal reflux interventions for chronic cough associated with gastro-oesophageal reflux. BMJ 2006;332:11–7. Q What is the efficacy of various treatments for gastro-oesophageal reflux for prolonged non-specific cough in adults and children?Data sources:Medline (1966–2004), OldMedline (1951–65), EMBASE/Excerpta Medica (1997–2004), Cochrane Controlled Trials Register (searches current as of April 2005); reference lists of relevant studies; and communication with authors.Study selection and assessment:randomised controlled trials (RCTs) of adults and children receiving any gastro-oesophageal reflux disease (GORD) treatment (ie, anti-reflux conservative measures, H2 receptor antagonists, proton pump inhibitors [PPIs], or surgical therapy) for chronic non-specific cough lasting ⩾3 weeks (dry, non-productive cough without any other respiratory symptoms, signs, or systemic illness). 12 RCTs met the selection criteria; 3 … ER -