TY - JOUR T1 - Review: high dose vitamin E supplementation is associated with increased all cause mortality JF - Evidence Based Nursing JO - Evid Based Nurs SP - 82 LP - 82 DO - 10.1136/ebn.8.3.82 VL - 8 IS - 3 A2 - , Y1 - 2005/07/01 UR - http://ebn.bmj.com/content/8/3/82.abstract N2 - Miller ER 3rd, Pastor-Barriuso R, Dalal D, et al. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005;142:37–46.OpenUrlCrossRefPubMedWeb of Science Q Does vitamin E supplementation increase all cause mortality? Does a dose-response relation exist between vitamin E and all cause mortality? Data sources:Medline (1966 to August 2004), Cochrane Central Register of Controlled Trials, bibliographies of relevant studies and reviews, and personal files of the investigators.Study selection and assessment:randomised controlled trials (RCTs) that compared vitamin E supplementation (alone or combined with other vitamins or minerals) with a control or placebo group in men or non-pregnant women, study duration and follow up were >1 year, and ⩾10 deaths occurred.Outcomes:all cause mortality.19 RCTs (n = 135 967, mean age range 47–84 y) met the selection … ER -