TY - JOUR T1 - Maintenance and symptom relief with budesonide plus formoterol reduced severe asthma exacerbations JF - Evidence Based Nursing JO - Evid Based Nurs SP - 78 LP - 78 DO - 10.1136/ebn.8.3.78 VL - 8 IS - 3 A2 - , Y1 - 2005/07/01 UR - http://ebn.bmj.com/content/8/3/78.abstract N2 - O’Byrne PM, Bisgaard H, Godard PP, et al. Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma. Am J Respir Crit Care Med 2005;171:129–36.OpenUrlCrossRefPubMedWeb of Science Q In patients with asthma, is budesonide (BUD) plus formoterol (FORM) (BUDFORM) for both maintenance and symptom relief more effective than fixed dosing using BUDFORM or a 4 fold higher dose of BUD, both with a short acting β2 agonist (SABA), for reducing the rate of severe asthma exacerbations? Design:randomised controlled trial.Allocation:concealed.Blinding:blinded (patients and healthcare providers).Follow up period:1 yearSetting:246 centres in 22 countries.Patients:2760 outpatients (mean age 36 y, 55% women/girls; 12% children 4–11 y) with asthma who were using inhaled corticosteroids (ICSs).Intervention:BUDFORM (BUD, 80 μg plus FORM, 4.5 μg) both for … ER -