TY - JOUR T1 - Methylprednisolone was associated with an increase in death after head injury JF - Evidence Based Nursing JO - Evid Based Nurs SP - 51 LP - 51 DO - 10.1136/ebn.8.2.51 VL - 8 IS - 2 A2 - , Y1 - 2005/04/01 UR - http://ebn.bmj.com/content/8/2/51.abstract N2 - CRASH Trial Collaborators. Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. Lancet 2004;364:1321–8.OpenUrlCrossRefPubMedWeb of Science Q In patients with head injury, is early administration of methylprednisolone better than placebo for reducing death? Design:randomised placebo controlled trial (Corticosteroid Randomisation After Significant Head injury [CRASH]).Allocation:concealed.Blinding:blinded (clinicians and patients).Follow up period:2 weeks.Setting:239 hospitals in 49 countries.Patients:10 008 patients who were ⩾16 years of age (mean age 37 y, 81% men) and had sustained a head injury within 8 hours, had a Glasgow Coma Score (GCS) ⩽14, and whose treating physician was uncertain whether to treat with corticosteroids.Intervention:a loading dose of methylprednisolone, 2 g over 1 hour in a 100 ml infusion, followed up by a maintenance … ER -