TY - JOUR T1 - Fluconazole reduced the rate of recurrence of vulvovaginal candidiasis JF - Evidence Based Nursing JO - Evid Based Nurs SP - 49 LP - 49 DO - 10.1136/ebn.8.2.49 VL - 8 IS - 2 A2 - , Y1 - 2005/04/01 UR - http://ebn.bmj.com/content/8/2/49.abstract N2 - Sobel JD, Wiesenfeld HC, Martens M, et al. Maintenance fluconazole therapy for recurrent vulvovaginal candidiasis. N Engl J Med 2004;351:876–83.OpenUrlCrossRefPubMedWeb of Science Q What is the efficacy of fluconazole for recurrent vulvovaginal candidiasis (VC)? Design:randomised placebo controlled trial.Allocation:unclear.Blinding:blinded (patients and healthcare providers).Follow up period:12 months.Setting:multiple centres in the US.Patients:387 women ⩾18 years of age (mean age 34 y, 67% white) who had active, acute candida vaginitis (severity score ⩾3), a positive result on microscopic examination of vaginal secretions, ⩾4 episodes of candida vaginitis in the previous 12 months, and were clinically cured (severity score <3) at 14 days after receiving 3 sequential doses of fluconazole, 150 mg, at 72 hour intervals. Exclusion criteria: lack of confirmation of microscopic findings by culture, pregnancy, mixed infections or known seropositivity for HIV, or use of antifungal agents in the previous 4 weeks.Intervention:a single oral dose of fluconazole, … ER -