TY - JOUR T1 - Infusion of low dose dopamine did not reduce renal failure in at risk patients in the intensive care unit JF - Evidence Based Nursing JO - Evid Based Nurs SP - 118 LP - 118 DO - 10.1136/ebn.4.4.118 VL - 4 IS - 4 A2 - , Y1 - 2001/10/01 UR - http://ebn.bmj.com/content/4/4/118.abstract N2 - Bellomo R, Chapman M, Finfer S, et al. Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trial Group.Lancet2000 Dec 23/30;356:2139–43OpenUrlCrossRefPubMedWeb of Science QUESTION: Does low dose dopamine decrease the risk of renal failure in at risk patients in the intensive care unit (ICU)?Randomised (allocation concealed), blinded (patients, clinicians, outcome assessors, data analysts), controlled trial with follow up to defined study events.23 ICUs in Australia, New Zealand, and Hong Kong.328 patients who had central venous catheters, ≥2 pathophysiological changes of the systemic inflammatory response syndrome (SIRS) over a 24 hour period, and ≥1 indicator of early renal dysfunction (mean urine output <0.5 ml/kg/h over ≥4 h, serum creatinine concentration >150 μmol/l with no premorbid renal dysfunction, increase in serum creatinine concentration of >80 μmol/l in <24 h without creatine kinase >5000 IU/l or myoglobin in the urine). Exclusion criteria were age <18 years, episode of acute renal failure … ER -