TY - JOUR T1 - Children's adverse reactions to subsequent peanut exposure were often more serious than symptoms experienced in initial reactions JF - Evidence Based Nursing JO - Evid Based Nurs SP - 91 LP - 91 DO - 10.1136/ebn.4.3.91 VL - 4 IS - 3 A2 - , Y1 - 2001/07/01 UR - http://ebn.bmj.com/content/4/3/91.abstract N2 - Vander Leek TK, Liu AH, Stefanski K, et al.The natural history of peanut allergy in young children and its association with serum peanut-specific IgE.J Pediatr2000 Dec;137:749–55OpenUrlCrossRefPubMedWeb of Science QUESTION: In young children with peanut allergy, what is the nature and rate of adverse reactions caused by accidental peanut exposure? Prospective cohort study with a median of 5.9 years (range 1.4–22.4 y) of follow up.Boulder, Colorado, USA.102 children with clinical peanut hypersensitivity diagnosed before their fourth birthday. Children were included if they had a convincing history of clinical peanut hypersensitivity, a positive double blind, placebo controlled food challenge response to peanuts, or both; and a positive skin prick test response to peanuts. 83 children (81%) (median age 2.4 y, 69% boys) were included in the analysis.Severity of symptoms (non-life threatening or potentially life threatening) and organ system involvement (skin, respiratory, gastrointestinal, or other) with symptoms … ER -