TY - JOUR T1 - Aspirin but not vitamin E prevented cardiovascular events in patients at risk JF - Evidence Based Nursing JO - Evid Based Nurs SP - 86 LP - 86 DO - 10.1136/ebn.4.3.86 VL - 4 IS - 3 A2 - , Y1 - 2001/07/01 UR - http://ebn.bmj.com/content/4/3/86.abstract N2 - Collaborative Group of the Primary Prevention Project (PPP).Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice.Lancet2001 Jan 13;357:89–95OpenUrlCrossRefPubMedWeb of Science QUESTION: In patients with ≥1 cardiovascular risk factor but no history of cardiovascular disease, do aspirin and vitamin E prevent cardiovascular events? Randomised (allocation concealed), unblinded, 2 × 2 factorial trial with a mean follow up of 3.6 years.315 general practices and 15 hospital hypertension units in Italy.4495 patients (mean age 64 y, 58% women) aged ≥50 years who had ≥1 major cardiovascular risk factor: age ≥65 years, hypertension, hypercholesterolaemia, diabetes mellitus, obesity, and family history of myocardial infarction (MI) before 55 years of age in ≥1 parent or sibling. Exclusion criteria were treatment with antiplatelet drugs, chronic use of anti-inflammatory agents or anticoagulants, contraindication … ER -