TY - JOUR T1 - Review: antiviral agents reduce risk of influenza in healthy adults and alleviate symptoms faster than placebo JF - Evidence Based Nursing JO - Evid Based Nurs SP - 108 LP - 108 DO - 10.1136/ebn.9.4.108 VL - 9 IS - 4 A2 - , Y1 - 2006/10/01 UR - http://ebn.bmj.com/content/9/4/108.abstract N2 - Jefferson T, Demicheli V, Rivetti D, et al. Antivirals for influenza in healthy adults: systematic review. Lancet 2006;367:303–13.OpenUrlCrossRefPubMedWeb of Science Q In healthy adults, do antiviral agents reduce the risk of influenza and improve outcomes in affected people?Data sources:Medline (August 2005), EMBASE/Excerpta Medica (June 2005), Cochrane Central Register of Controlled Trials (Issue 3, 2005), and bibliographies of relevant systematic reviews and retrieved trials.Study selection and assessment:randomised controlled trials (RCTs) that compared amantadine, rimantadine, or neuraminidase inhibitors (oseltamivir and zanamivir) with placebo, no treatment, or symptomatic treatment for prophylaxis or treatment of influenza in otherwise healthy people 16–65 years of age. 53 RCTs met the selection criteria.Outcomes:cases of symptomatic or asymptomatic influenza (confirmed by laboratory testing) and influenza-like illness (ILI) … ER -