TY - JOUR T1 - Oestrogen plus progestogen increased risk of breast cancer in postmenopausal women JF - Evidence Based Nursing JO - Evid Based Nurs SP - 16 LP - 16 DO - 10.1136/ebn.7.1.16 VL - 7 IS - 1 A2 - , Y1 - 2004/01/01 UR - http://ebn.bmj.com/content/7/1/16.abstract N2 - Chlebowski RT, Hendrix SL, Langer RD, et al. Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women’s Health Initiative Randomized Trial. JAMA 2003;289:3243–53.OpenUrlCrossRefPubMedWeb of Science Q In postmenopausal women, does oestrogen plus progestogen hormone therapy increase the risk of abnormal mammographic results and diagnosis of breast cancer? Design:randomised, placebo controlled trial (Women’s Health Initiative).Allocation:concealed.Blinding:blinded (clinicians, participants, data collectors, outcome assessors, and monitoring committee).Follow up period:mean 5.6 years.Setting:40 US clinical centres.Patients:16 608 postmenopausal women who were 50–79 years of age (mean age 63 y). Exclusion criteria: previous hysterectomy, breast cancer, or probable survival <3 years.Interventions:1 daily tablet of conjugated equine oestrogen, … ER -