TY - JOUR T1 - Vaccinating infants with a wide long needle achieved comparable immune response and reduced local reactions compared with a narrow short needle JF - Evidence Based Nursing JO - Evid Based Nurs SP - 43 LP - 43 DO - 10.1136/ebn.10.2.43 VL - 10 IS - 2 A2 - , Y1 - 2007/04/01 UR - http://ebn.bmj.com/content/10/2/43.abstract N2 - Diggle L, Deeks JJ, Pollard AJ. Effect of needle size on immunogenicity and reactogenicity of vaccines in infants: randomised controlled trial. BMJ 2006;333:571.OpenUrlAbstract/FREE Full Text Q Is vaccination of infants with a wide long needle equivalent or superior to a narrow short needle for immune response and local reactions?Design:randomised controlled non-inferiority trial.Allocation:concealed.Blinding:blinded (data entry clerks and laboratory staff).Follow up period:3 to 4.5 months.Setting:18 general practices in 2 primary care trusts in the UK.Participants:696 healthy infants due to receive their first immunisation (mean age 62 d, mean weight 5300 g, 52% boys). Exclusion criteria were <37 weeks gestation, birth weight <2500 g, or treatments or conditions that could bias evaluation of immune response.Intervention:vaccination with a 23 gauge, 25 mm needle (wide long needle, n = 240), a 25 gauge, 16 mm needle (narrow short needle, n = 230), or a 25 gauge, 25 mm needle (narrow long needle, … ER -