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Nursing issues
Genetic risk assessment can identify women with high venous thromboembolism risk contributing to precision medicine and personalised care
  1. Nashit Chowdhury1,2,
  2. Tanvir C Turin1,2
  1. 1Department of Family Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
  2. 2Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
  1. Correspondence to Dr Tanvir C Turin; turin.chowdhury{at}ucalgary.ca

https://doi.org/10.1136/ebnurs-2023-103890

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    Commentary on: Lo Faro V, Johansson T, Johansson Å. The risk of venous thromboembolism in oral contraceptive users: the role of genetic factors—a prospective cohort study of 2 40 000 women in the UK Biobank. Am J Obstet Gynecol. 2024;230:360.e1-13

    Implications for practice and research

    • Currently, venous thromboembolism (VTE) risk assessment for contraceptive counselling is based on clinical characteristics and family history. Incorporating genetic risk assessment into current practice can significantly enhance the screening of oral contraceptive users at high risk for VTE.

    • Further research is needed to develop a comprehensive model, explore the cost-effectiveness and implementation of genetic risk assessment in contraceptive counselling, address challenges in communicating genetic information and evaluate its applicability across diverse populations.

    Context

    Venous thromboembolism (VTE) is a complex disorder influenced by both acquired and inherited factors. Oral contraceptive use, an acquired factor, has been linked to an increased risk of VTE. Regarding inherited factors, women who are carriers of certain thrombophilia gene …

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    Footnotes

    • Competing interests None declared.

    • Provenance and peer review Commissioned; internally peer reviewed.