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Chelating and antibiotic locks may be effective in the prevention of central venous access device-associated bloodstream infections in the paediatric population
  1. Linda J Kelly
  1. Vascular Management, Vygon, Ecouen, France
  1. Correspondence to Dr Linda J Kelly, Global Clinical Specialist, Vascular Management, Vygon, Ecouen, France; linda.kelly{at}

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Commentary on: Takashima, M et al. Pediatric Central Venous Access Device Lock Solutions: A Network Meta-analysis.

Implications for practice and research

  • Chelating and antibiotic locks should be considered for prevention of central venous access device (CVAD)-associated bloodstream infection (BSI) in paediatric patients.

  • Further research with larger sample sizes is necessary to gain a more accurate insight into the potential impact of lock solutions on the treatment of CVAD-associated BSI.


Central venous access devices (CVADs) are required by children to allow the safe delivery of intravenous therapies that must be delivered in the large central veins of the body. CVADs are associated with many complications such as infections, thrombosis and occlusions.1 A strategy used to prevent such complications is to instil a solution into the catheter to provide a ‘lock’. There are many ‘lock solutions’ available and used within paediatric …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.