Article Text

Download PDFPDF
Statins improve antidepressant adherence and tolerability compared to antidepressants alone
  1. Neil Aggarwal
  1. New York State Psychiatric Institute, Columbia University, New York, New York, USA
  1. Correspondence to Dr Neil Aggarwal, New York State Psychiatric Institute, Columbia University, New York, New York, USA; aggarwa{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Commentary on: De Giorgi R, De Crescenzo F, Cowen PJ, Harmer CJ, Cipriani A. Real-world outcomes of concomitant antidepressant and statin use in primary care patients with depression: a population-based cohort study. BMC Med. 2023 Nov 7;21(1):424. doi: 10.1186/s12916-023-03138-5.

Implications for practice and research

  • Providers should encourage antidepressant use with statins for depression that is comorbid with physical conditions.

  • Research can clarify which population subgroups taking both medications demonstrate improved outcomes.


Depression affects more than 350 million people worldwide.1 Even though guidelines support using antidepressants to treat moderate and severe depression, nearly 50% of people do not respond to antidepressants2 and 25% discontinue them.3 Studies suggest that adding statins to antidepressants can improve antidepressant adherence, but these studies have been underpowered to test outcomes.4


De Giorgi and colleagues used …

View Full Text


  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.