You are here

  • Home
  • Online First
  • Low-dose aspirin as a promising agent for the prevention of spontaneous preterm birth

Article Text

Article menu

other Versions

Download PDFPDF
Commentary
Women’s health and midwifery
Low-dose aspirin as a promising agent for the prevention of spontaneous preterm birth
  1. Anadeijda J E M C Landman1,
  2. Martijn A Oudijk2
  1. 1 Department of Obstetrics & Gynaecology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development, de Boelelaan 1117, Amsterdam, the Netherlands
  2. 2 Department of Obstetrics & Gynaecology, Amsterdam UMC, University of Amsterdam, Amsterdam Reproduction & Development, Meibergdreef 9, Amsterdam, the Netherlands
  1. Correspondence to Dr. Martijn A Oudijk, Amsterdam UMC, University of Amsterdam, Department of Obstetrics & Gynaecology, Amsterdam Reproduction & Development, Meibergdreef 9, Amsterdam, the Netherlands; m.a.oudijk{at}amc.uva.nl

https://doi.org/10.1136/ebnurs-2018-102998

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Commentary on: Andrikopoulou M, Purisch SE, Handal-Orefice R, et al. Low-dose aspirin is associated with reduced spontaneous preterm birth in nulliparous women. Am J Obstet Gynecol. 2018;219:399.e1–399.e6.

    Implications for practice and research

    • At this moment, there is insufficient evidence to implement low-dose aspirin for the prevention of spontaneous preterm birth.

    • Placebo-controlled randomised controlled trials are needed to confirm the effectiveness of aspirin for the prevention of spontaneous preterm birth.

    Context

    Preterm birth is the most important cause of perinatal morbidity and mortality worldwide. Despite the administration of progesterone to women with a previous spontaneous preterm birth, ~20%–30% will deliver preterm again.1 Accumulating evidence suggests that uteroplacental ischaemia plays an important role in the aetiology of spontaneous preterm birth, comparable to its role in preeclampsia. As aspirin …

    View Full Text

    Footnotes

    • Competing interests None declared.

    • Provenance and peer review Commissioned; internally peer reviewed.