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Randomised controlled trial
A fortified follow-up formula for 3–4-year-olds reduces episodes of acute respiratory infection and antibiotic use compared with cow’s milk
  1. Herman T den Dekker1,2,
  2. Liesbeth Duijts1,2,3
  1. 1Department of Pediatrics, Division of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands;
  2. 2Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands;
  3. 3Department of Pediatrics, DIvision of Neonatology, Erasmus Medical Center, Rotterdam, The Netherlands
  1. Correspondence to: Dr Liesbeth Duijts, Department of Pediatrics, Division of Respiratory Medicine, Erasmus Medical Center, P.O. Box 2040, Rotterdam 3000 CA, The Netherlands; l.duijts{at}

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Commentary on: OpenUrlAbstract/FREE Full Text

Implications for practice and research

  • Follow-up formula enriched with prebiotic components and yeast β-glucan might decrease the incidence and duration of respiratory tract infections in childhood.

  • It is unclear which specific additive of the follow-up formula or the role of other dietary habits has the most beneficial effect in relation to the incidence of respiratory tract infections.

  • Further studies are needed to improve understanding of the role of additives in follow-up formula feeding on the risk of communicable diseases in childhood.


Respiratory infections and diarrhoea are major causes of childhood morbidity.1 The use of dietary supplements may have beneficial effects on the immune system …

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  • Competing interests None.