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Treatment
Maintenance treatment with paroxetine, but not psychotherapy, prevented recurrent major depression in older people

https://doi.org/10.1136/ebn.9.4.119

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    Reynolds CF 3rd, Dew MA, Pollock BG, et al. Maintenance treatment of major depression in old age. N Engl J Med 2006;354:1130–8.OpenUrlCrossRefPubMedWeb of Science

    Q In elderly patients with major depression who respond to treatment, does maintenance treatment with paroxetine, psychotherapy, or a combination thereof prevent recurrence of depression?

    METHODS

    Embedded ImageDesign:

    randomised, 2 × 2 factorial design, placebo controlled trial.

    Embedded ImageAllocation:

    concealed.*

    Embedded ImageBlinding:

    blinded (clinicians, patients, and outcome assessors). Clinicians and patients were not blinded to the psychotherapy intervention.

    Embedded ImageFollow up period:

    2 years.

    Embedded ImageSetting:

    specialised university based clinic in Pittsburgh, Pennsylvania, USA.

    Embedded ImagePatients:

    116 patients ⩾70 years of age (mean age 77 y, 65% women) who had major depression according to Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria, scores ⩾15 on the Hamilton …

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    Footnotes

    • ↵* Information provided by author.

    • For correspondence: Dr C F Reynolds, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA. reynoldscf{at}upmc.edu

    • Sources of funding: National Institute of Mental Health and National Center for Minority Health and Health Disparities.