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Maintenance treatment with paroxetine, but not psychotherapy, prevented recurrent major depression in older people

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Q In elderly patients with major depression who respond to treatment, does maintenance treatment with paroxetine, psychotherapy, or a combination thereof prevent recurrence of depression?


Embedded ImageDesign:

randomised, 2 × 2 factorial design, placebo controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (clinicians, patients, and outcome assessors). Clinicians and patients were not blinded to the psychotherapy intervention.

Embedded ImageFollow up period:

2 years.

Embedded ImageSetting:

specialised university based clinic in Pittsburgh, Pennsylvania, USA.

Embedded ImagePatients:

116 patients ⩾70 years of age (mean age 77 y, 65% women) who had major depression according to Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria, scores ⩾15 on the Hamilton …

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  • * Information provided by author.

  • For correspondence: Dr C F Reynolds, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA. reynoldscf{at}

  • Sources of funding: National Institute of Mental Health and National Center for Minority Health and Health Disparities.