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Calcium plus vitamin D did not prevent fractures or colorectal cancer in postmenopausal women

https://doi.org/10.1136/ebn.9.4.114

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    Jackson RD, LaCroix AZ, Gass M, et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006;354:669–83.OpenUrlCrossRefPubMedWeb of ScienceWactawski-Wende J, Kotchen JM, Anderson GL, et al. Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med 2006;354:684–96.OpenUrlCrossRefPubMedWeb of Science

    Q In postmenopausal women, does supplementation with calcium and vitamin D reduce fractures or colorectal cancer?

    METHODS

    Embedded ImageDesign:

    randomised, placebo controlled trial (Women’s Health Initiative [WHI] calcium with vitamin D trial).

    Embedded ImageAllocation:

    {concealed}.*

    Embedded ImageBlinding:

    blinded {participants, clinicians, data collectors, outcome assessors, adjudicators, and manuscript writers}.*

    Embedded ImageFollow up period:

    mean 7 years.

    Embedded ImageSetting:

    40 centres in the US. …

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    Footnotes

    • ↵* Information provided by authors.

    • For correspondence: Dr R D Jackson, Ohio State University, Columbus, OH, USA. jackson.20{at}osu.edu Dr J Wactawski-Wende, University at Buffalo, Buffalo, NY, USA. jww{at}buffalo.edu

    • Sources of funding: National Heart, Lung and Blood Institute, National Center for Research Resources, and GlaxoSmithKline.