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Calcium plus vitamin D did not prevent fractures or colorectal cancer in postmenopausal women

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Q In postmenopausal women, does supplementation with calcium and vitamin D reduce fractures or colorectal cancer?


Embedded ImageDesign:

randomised, placebo controlled trial (Women’s Health Initiative [WHI] calcium with vitamin D trial).

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {participants, clinicians, data collectors, outcome assessors, adjudicators, and manuscript writers}.*

Embedded ImageFollow up period:

mean 7 years.

Embedded ImageSetting:

40 centres in the US. …

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  • * Information provided by authors.

  • For correspondence: Dr R D Jackson, Ohio State University, Columbus, OH, USA. jackson.20{at} Dr J Wactawski-Wende, University at Buffalo, Buffalo, NY, USA. jww{at}

  • Sources of funding: National Heart, Lung and Blood Institute, National Center for Research Resources, and GlaxoSmithKline.