Article Text

Download PDFPDF
Review: antiviral agents reduce risk of influenza in healthy adults and alleviate symptoms faster than placebo

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

OpenUrlCrossRefPubMedWeb of Science

Q In healthy adults, do antiviral agents reduce the risk of influenza and improve outcomes in affected people?


Embedded ImageData sources:

Medline (August 2005), EMBASE/Excerpta Medica (June 2005), Cochrane Central Register of Controlled Trials (Issue 3, 2005), and bibliographies of relevant systematic reviews and retrieved trials.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs) that compared amantadine, rimantadine, or neuraminidase inhibitors (oseltamivir and zanamivir) with placebo, no treatment, or symptomatic treatment for prophylaxis or treatment of influenza in otherwise healthy people 16–65 years of age. 53 RCTs met the selection criteria.

Embedded ImageOutcomes:

cases of symptomatic or asymptomatic influenza (confirmed by laboratory testing) and influenza-like illness (ILI) …

View Full Text


  • For correspondence: Dr T Jefferson, Cochrane Vaccines Field, Alessandria, Italy. Jefferson.tom{at}

  • Sources of funding: UK Department of Health; Cochrane Review Incentive Scheme 2005; ASL 20, Alessandria and ASL 19, Asti, Italy.