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Treatment
Review: antiviral agents reduce risk of influenza in healthy adults and alleviate symptoms faster than placebo

https://doi.org/10.1136/ebn.9.4.108

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    Jefferson T, Demicheli V, Rivetti D, et al. Antivirals for influenza in healthy adults: systematic review. Lancet 2006;367:303–13.OpenUrlCrossRefPubMedWeb of Science

    Q In healthy adults, do antiviral agents reduce the risk of influenza and improve outcomes in affected people?

    METHODS

    Embedded ImageData sources:

    Medline (August 2005), EMBASE/Excerpta Medica (June 2005), Cochrane Central Register of Controlled Trials (Issue 3, 2005), and bibliographies of relevant systematic reviews and retrieved trials.

    Embedded ImageStudy selection and assessment:

    randomised controlled trials (RCTs) that compared amantadine, rimantadine, or neuraminidase inhibitors (oseltamivir and zanamivir) with placebo, no treatment, or symptomatic treatment for prophylaxis or treatment of influenza in otherwise healthy people 16–65 years of age. 53 RCTs met the selection criteria.

    Embedded ImageOutcomes:

    cases of symptomatic or asymptomatic influenza (confirmed by laboratory testing) and influenza-like illness (ILI) …

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    Footnotes

    • For correspondence: Dr T Jefferson, Cochrane Vaccines Field, Alessandria, Italy. Jefferson.tom{at}gmail.com

    • Sources of funding: UK Department of Health; Cochrane Review Incentive Scheme 2005; ASL 20, Alessandria and ASL 19, Asti, Italy.