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Medline (August 2005), EMBASE/Excerpta Medica (June 2005), Cochrane Central Register of Controlled Trials (Issue 3, 2005), and bibliographies of relevant systematic reviews and retrieved trials.
Study selection and assessment:
randomised controlled trials (RCTs) that compared amantadine, rimantadine, or neuraminidase inhibitors (oseltamivir and zanamivir) with placebo, no treatment, or symptomatic treatment for prophylaxis or treatment of influenza in otherwise healthy people 16–65 years of age. 53 RCTs met the selection criteria.
cases of symptomatic or asymptomatic influenza (confirmed by laboratory testing) and influenza-like illness (ILI) …
For correspondence: Dr T Jefferson, Cochrane Vaccines Field, Alessandria, Italy.
Sources of funding: UK Department of Health; Cochrane Review Incentive Scheme 2005; ASL 20, Alessandria and ASL 19, Asti, Italy.