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Review: vaccines prevent influenza and influenza-like illness in healthy children <16 years of age

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Q In healthy children <16 years of age, are influenza vaccines efficacious (ie, prevent confirmed influenza) and effective (ie, prevent influenza-like illness)?


Embedded ImageData sources:

Medline (1966–2004), EMBASE/Excerpta Medica (1974–2004), Cochrane Library (Issue 1, 2005), Biological Abstracts (1969–2004), Science Citation Index (1974–2004), Vaccine Adverse Event Reporting System website (, vaccine manufacturers, and authors of relevant studies.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs), semi-randomised, cohort, and case-control studies in any language that enrolled healthy children <16 years of age in any geographical location; compared any influenza vaccine (including unlicensed types) …

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  • For correspondence: Dr S Smith, Oxford University, Oxford, UK.

  • Source of funding: no funding.

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