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Adding topical pale sulfonated shale oil to compression therapy and moist wound care reduced venous leg ulcer size but had no effect on complete wound healing after 20 weeks

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Q Does topical application of pale sulfonated shale oil (PSSO) in addition to usual care with compression therapy and standard moist wound care improve healing of venous leg ulcers?


Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {patients, healthcare providers, data collectors, and outcome assessors}.*

Embedded ImageFollow up period:

to the end of the 20 week treatment period.

Embedded ImageSetting:

13 outpatient wound clinics in Germany and Slovakia.

Embedded ImagePatients:

119 patients >18 years of age (mean age 69 y, 67% women) who had leg ulcers ⩾3 cm2 caused by chronic venous insufficiency. Exclusion criteria were severe cardiac, respiratory, gastrointestinal, liver, or renal disease; malignancy; signs of wound infection; and pregnancy or lactation.

Embedded ImageIntervention:

10% Leukichtan PSSO gel (Ichthyol-Gesellschaft, Germany) (n = 62) or placebo gel (n = 57). Both gels were applied daily …

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  • * Information provided by author.

  • * Calculated from data in original article.

  • For correspondence: Dr S Beckert, Department of General and Transplant Surgery, Hoppe-Seyler-Str 3, Tübingen, Germany. stefan.beckert{at}

  • Source of funding: no external funding.