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Oestrogen and progestin increased urge and stress incontinence in postmenopausal women with coronary heart disease

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Q In postmenopausal women with coronary heart disease, does oestrogen and progestin treatment affect the risk of stress and urge urinary incontinence (UI)?


Embedded ImageDesign:

secondary analysis of a randomised placebo controlled trial (Heart Estrogen/progestin Replacement Study [HERS]).

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {patients, investigators, and outcome assessors}.*

Embedded ImageFollow up period:

4–48 months.

Embedded ImageSetting:

20 clinical centres in the US.

Embedded ImagePatients:

1228 postmenopausal women <80 years of age who had coronary heart disease, an intact uterus, and reported no episodes of UI within the past week. {Exclusion criteria included use of oral, parenteral, vaginal, or transdermal hormones within 3 months; …

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  • For correspondence: Dr J E Steinauer, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California-San Francisco, San Francisco, CA, USA

  • Source of funding: Wyeth-Ayerst Research.