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Oestrogen and progestin increased urge and stress incontinence in postmenopausal women with coronary heart disease

https://doi.org/10.1136/ebn.9.3.84

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    Steinauer JE, Waetjen LE, Vittinghoff E, et al, for the Heart and Estrogen/Progestin Replacement Study Research Group. Postmenopausal hormone therapy: does it cause incontinence? Obstet Gynecol 2005;106:940–5.OpenUrlPubMedWeb of Science

    Q In postmenopausal women with coronary heart disease, does oestrogen and progestin treatment affect the risk of stress and urge urinary incontinence (UI)?

    METHODS

    Embedded ImageDesign:

    secondary analysis of a randomised placebo controlled trial (Heart Estrogen/progestin Replacement Study [HERS]).

    Embedded ImageAllocation:

    {concealed}.*

    Embedded ImageBlinding:

    blinded {patients, investigators, and outcome assessors}.*

    Embedded ImageFollow up period:

    4–48 months.

    Embedded ImageSetting:

    20 clinical centres in the US.

    Embedded ImagePatients:

    1228 postmenopausal women <80 years of age who had coronary heart disease, an intact uterus, and reported no episodes of UI within the past week. {Exclusion criteria included use of oral, parenteral, vaginal, or transdermal hormones within 3 months; …

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    Footnotes

    • ↵* Hulley S, Grady D, Bush T et al. Controlled Clin Trials 1998;19:314–35.OpenUrlCrossRefPubMedWeb of Science

    • For correspondence: Dr J E Steinauer, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California-San Francisco, San Francisco, CA, USA

    • Source of funding: Wyeth-Ayerst Research.