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  • Mechanical ventilation with heated humidifiers or with heat and moisture exchangers with microbiological filters did not reduce ventilator associated pneumonia in adults

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Mechanical ventilation with heated humidifiers or with heat and moisture exchangers with microbiological filters did not reduce ventilator associated pneumonia in adults

https://doi.org/10.1136/ebn.9.3.82

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    Lacherade JC, Auburtin M, Cerf C, et al. Impact of humidification systems on ventilator-associated pneumonia: a randomized multicenter trial. Am J Respir Crit Care Med 2005;172:1276–82.OpenUrlCrossRefPubMedWeb of Science

    Q Does the method of airway humidification (heat and moisture exchangers with microbiological filters [HMEFs] or heated humidifiers [HHs]) affect the incidence of ventilator associated pneumonia (VAP) in adults?

    METHODS

    Embedded ImageDesign:

    randomised controlled trial.

    Embedded ImageAllocation:

    concealed.

    Embedded ImageBlinding:

    blinded (microbiologists confirming VAP).

    Embedded ImageFollow up period:

    up to 28 days of mechanical ventilation.

    Embedded ImageSetting:

    5 intensive care units (ICUs) in 2 university affiliated teaching hospitals in France.

    Embedded ImagePatients:

    370 patients >18 years of age (mean age 55 y, 70% men) who required mechanical ventilation (eg, nasotracheal, orotracheal, or tracheostomy tube) for >48 hours. Exclusion criteria were previous ventilation for >24 hours, contraindications to HHs (eg, active …

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    Footnotes

    • For correspondence: Dr L Brochard, Reanimation Medicale, CHU Henri Mondor, Creteil, France. laurent.brochard{at}hmn.aphp.fr

    • Source of funding: Fisher and Paykel Healthcare provided equipment.