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Review: routine changes of IV administration sets (not containing lipids or blood products) at intervals ⩽96 hours do not affect infusate or catheter related bloodstream infection

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Q What is the optimal interval for routine replacement of IV administration sets when infusate or parenteral nutrition solutions are administered by central or peripheral venous catheters?


Embedded ImageData sources:

Cochrane Central Register of Controlled Trials, Medline, CINAHL, and EMBASE/Excerpta Medica (all up to February 2004); reference lists; and researchers.

Embedded ImageStudy selection and assessment:

randomised or quasi-randomised controlled trials that assessed the effects of different frequencies of replacing IV administration sets among inpatients of any age receiving parenteral nutrition (lipid and non-lipid containing solutions) or infusions (excluding blood) by central or peripheral catheter. 13 studies (n = 4783) met the selection criteria. Methodological quality of individual studies was assessed based on allocation concealment and loss to follow up. …

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  • For correspondence: Dr D Gillies, Sydney West Area Health Service, Parramatta BC, New South Wales, Australia. Donna_Gillies{at}

  • Source of funding: not stated.