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  • Review: insufficient evidence exists on the effectiveness of proton pump inhibitors for adults with prolonged non-specific cough associated with gastro-oesophageal reflux

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Review: insufficient evidence exists on the effectiveness of proton pump inhibitors for adults with prolonged non-specific cough associated with gastro-oesophageal reflux

https://doi.org/10.1136/ebn.9.3.73

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    Chang AB, Lasserson TJ, Gaffney J, et al. Gastro-oesophageal reflux treatment for prolonged non-specific cough in children and adults. Cochrane Database Syst Rev 2005;(2):CD004823.Chang AB, Lasserson TJ, Kiljander TO, et al. Systematic review and meta-analysis of randomised controlled trials of gastro-oesophageal reflux interventions for chronic cough associated with gastro-oesophageal reflux. BMJ 2006;332:11–7.

    Q What is the efficacy of various treatments for gastro-oesophageal reflux for prolonged non-specific cough in adults and children?

    METHODS

    Embedded ImageData sources:

    Medline (1966–2004), OldMedline (1951–65), EMBASE/Excerpta Medica (1997–2004), Cochrane Controlled Trials Register (searches current as of April 2005); reference lists of relevant studies; and communication with authors.

    Embedded ImageStudy selection and assessment:

    randomised controlled trials (RCTs) of adults and children receiving any gastro-oesophageal reflux disease (GORD) treatment (ie, anti-reflux conservative measures, H2 receptor antagonists, proton pump inhibitors [PPIs], or surgical therapy) for chronic non-specific cough lasting ⩾3 weeks (dry, non-productive cough without any other respiratory symptoms, signs, or systemic illness). 12 RCTs met the selection criteria; 3 …

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    Footnotes

    • For correspondence: Dr A B Chang, Royal Children’s Hospital, Brisbane, Queensland, Australia. annechang{at}ausdoctors.net

    • Sources of funding: National Health and Medical Research Council Australia and Cochrane Child Health Field Bursary Scheme Canada.