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Review: insufficient evidence exists on the effectiveness of proton pump inhibitors for adults with prolonged non-specific cough associated with gastro-oesophageal reflux

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Q What is the efficacy of various treatments for gastro-oesophageal reflux for prolonged non-specific cough in adults and children?


Embedded ImageData sources:

Medline (1966–2004), OldMedline (1951–65), EMBASE/Excerpta Medica (1997–2004), Cochrane Controlled Trials Register (searches current as of April 2005); reference lists of relevant studies; and communication with authors.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs) of adults and children receiving any gastro-oesophageal reflux disease (GORD) treatment (ie, anti-reflux conservative measures, H2 receptor antagonists, proton pump inhibitors [PPIs], or surgical therapy) for chronic non-specific cough lasting ⩾3 weeks (dry, non-productive cough without any other respiratory symptoms, signs, or systemic illness). 12 RCTs met the selection criteria; 3 …

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  • For correspondence: Dr A B Chang, Royal Children’s Hospital, Brisbane, Queensland, Australia. annechang{at}

  • Sources of funding: National Health and Medical Research Council Australia and Cochrane Child Health Field Bursary Scheme Canada.