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randomised controlled trial (RCT).
blinded (patients, surgical team, data collectors, outcome assessors, and monitoring committee).
Follow up period:
14 days after surgery.
14 hospitals in Spain.
300 patients 18–80 years of age who were having elective colorectal resection. Exclusion criteria were minor colon surgery (eg, polypectomy or isolated colostomy) or laparoscopic surgery, expected duration of surgery <1 hour, fever or existing signs of infection, diabetes mellitus, HIV infection, >20% weight loss in past 3 months, serum albumin concentration <30 g/l, or leucocyte count <2500 cells/ml.
during surgery, patients were administered an …
For correspondence: Dr F J Belda, Department of Anesthesiology and Critical Care, Hospital Clínico Universitario de Valencia, Valencia, Spain.
Sources of funding: in part, Air-Liquide Medicinal, Spain and Air-Liquide Santé, France.