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Supplemental perioperative oxygen at 80% FIO2 reduced surgical site infections in elective colorectal surgery

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Q In patients having elective colorectal resection, does supplemental perioperative oxygen reduce the risk of surgical site infection (SSI)?


Embedded ImageDesign:

randomised controlled trial (RCT).

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (patients, surgical team, data collectors, outcome assessors, and monitoring committee).

Embedded ImageFollow up period:

14 days after surgery.

Embedded ImageSetting:

14 hospitals in Spain.

Embedded ImagePatients:

300 patients 18–80 years of age who were having elective colorectal resection. Exclusion criteria were minor colon surgery (eg, polypectomy or isolated colostomy) or laparoscopic surgery, expected duration of surgery <1 hour, fever or existing signs of infection, diabetes mellitus, HIV infection, >20% weight loss in past 3 months, serum albumin concentration <30 g/l, or leucocyte count <2500 cells/ml.

Embedded ImageIntervention:

during surgery, patients were administered an …

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  • For correspondence: Dr F J Belda, Department of Anesthesiology and Critical Care, Hospital Clínico Universitario de Valencia, Valencia, Spain. fjbelda{at}

  • Sources of funding: in part, Air-Liquide Medicinal, Spain and Air-Liquide Santé, France.