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Review: once daily LMWH is as effective as twice daily LMWH for initial treatment of venous thromboembolism

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Q Is once daily low molecular weight heparin (LMWH) as effective (for reducing recurrent venous thromboembolism [VTE]) and as safe (with respect to major haemorrhagic events) as twice daily LMWH in the initial treatment of VTE?


Embedded ImageData sources:

Cochrane Peripheral Vascular Diseases Specialized Trials Register (up to April 2005), Cochrane Central Register of Controlled Trials (CENTRAL) (Cochrane Library, Issue 1, 2005), Medline (up to April 2005), EMBASE/Excerpta Medica (up to April 2005), and bibliographies of relevant articles.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs) in any language that compared (in an intention to treat analysis) once daily with twice daily use of a fixed dose of …

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  • For correspondence: MrC J van Dongen, University of Amsterdam, Amsterdam, The Netherlands. c.j.vandongen{at}

  • Source of funding: Scottish Executive UK.