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Treatment
Review: antibiotic prophylaxis reduces mortality in patients with neutropenia

https://doi.org/10.1136/ebn.9.2.50

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    Gafter-Gvili A, Fraser A, Paul M, et al. Meta-analysis: antibiotic prophylaxis reduces mortality in neutropenic patients. Ann Intern Med 2005;142:979–95.Gafter-Gvili A, Fraser A, Paul M, et al. Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy. Cochrane Database Syst Rev 2005;(4):CD004386.

    Q Does antibiotic prophylaxis, particularly fluoroquinolone prophylaxis, reduce mortality in patients with neutropenia?

    METHODS

    Embedded ImageData sources:

    Medline (1966–2004), EMBASE/Excerpta Medica (1980–2004), Cochrane Cancer Network register of trials (December 2004), Cochrane Library (Issue 4, 2004), and references of included studies and reviews.

    Embedded ImageStudy selection and assessment:

    published and unpublished randomised controlled trials (RCTs) in any language that compared antibiotic therapy with placebo, no intervention, or other antibiotics for prophylaxis of bacterial infection in patients with neutropenia. Individual study quality was assessed based on …

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    Footnotes

    • For correspondence: Dr A Gafter-Gvili, Department of Medicine, Rabin Medical Center, Petah-Tiqva, Israel. anatga{at}post.tau.ac.il

    • Source of funding: European Commission fifth framework International Society Technologies grant.