Article Text

Download PDFPDF
Paracetamol, non-steroidal anti-inflammatory drugs, and combination treatment did not differ for pain relief after musculoskeletal injury

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

OpenUrlCrossRefPubMedWeb of Science

Q What is the relative effectiveness of oral paracetamol (acetaminophen), oral non-steroidal anti-inflammatory drugs (NSAIDs), and combination treatment for acute pain relief after musculoskeletal injury?


Embedded ImageDesign:

randomised placebo controlled trial.

Embedded ImageAllocation:

unclear concealment.

Embedded ImageBlinding:

blinded (patients, healthcare providers, and outcome assessors).

Embedded ImageFollow up period:

5–8 days after initial presentation. Pain was assessed up to 3 days.

Embedded ImageSetting:

emergency department (ED) of a university teaching hospital in Hong Kong.

Embedded ImagePatients:

300 patients ⩾16 years of age (mean age 37 y, 59% men) who presented to the ED with a painful acute limb injury. Exclusion criteria were substance abuse; dementia; indigestion; peptic ulceration or haemorrhage; recent anticoagulation; pregnancy; adverse reactions to study drugs; …

View Full Text


  • For correspondence: Dr T H Rainer, Accident and Emergency Medicine Academic Unit, Chinese University of Hong Kong, Shatin, Hong Kong. rainer1091{at}

  • Source of funding: no external funding.