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  • Paracetamol, non-steroidal anti-inflammatory drugs, and combination treatment did not differ for pain relief after musculoskeletal injury

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Paracetamol, non-steroidal anti-inflammatory drugs, and combination treatment did not differ for pain relief after musculoskeletal injury

https://doi.org/10.1136/ebn.9.2.45

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    Woo WWK, Man S-Y, Lam PKW, et al. Randomized double-blind trial comparing oral paracetamol and oral nonsteroidal antiinflammatory drugs for treating pain after musculoskeletal injury. Ann Emerg Med 2005;46:352–61.OpenUrlCrossRefPubMedWeb of Science

    Q What is the relative effectiveness of oral paracetamol (acetaminophen), oral non-steroidal anti-inflammatory drugs (NSAIDs), and combination treatment for acute pain relief after musculoskeletal injury?

    METHODS

    Embedded ImageDesign:

    randomised placebo controlled trial.

    Embedded ImageAllocation:

    unclear concealment.

    Embedded ImageBlinding:

    blinded (patients, healthcare providers, and outcome assessors).

    Embedded ImageFollow up period:

    5–8 days after initial presentation. Pain was assessed up to 3 days.

    Embedded ImageSetting:

    emergency department (ED) of a university teaching hospital in Hong Kong.

    Embedded ImagePatients:

    300 patients ⩾16 years of age (mean age 37 y, 59% men) who presented to the ED with a painful acute limb injury. Exclusion criteria were substance abuse; dementia; indigestion; peptic ulceration or haemorrhage; recent anticoagulation; pregnancy; adverse reactions to study drugs; …

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    Footnotes

    • For correspondence: Dr T H Rainer, Accident and Emergency Medicine Academic Unit, Chinese University of Hong Kong, Shatin, Hong Kong. rainer1091{at}cuhk.edu.hk

    • Source of funding: no external funding.