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The WHO technique for intramuscular thigh vaccination in infants and toddlers had fewer adverse reactions than 2 other techniques

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Q In infants and toddlers, which of 3 techniques for giving intramuscular thigh vaccinations results in the fewest adverse reactions?


Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {participants and data collectors}.*

Embedded ImageFollow up period:

24 hours.

Embedded ImageSetting:

a general practice in Taree, New South Wales, Australia.

Embedded ImageParticipants:

375 consecutive healthy children who were 2, 4, 6, or 18 months of age.

Embedded ImageIntervention:

intramuscular injection into the anterolateral thigh of diphtheria-tetanus-acellular pertussis-hepatitis B vaccine (InfanrixHepB, GlaxoSmithKline) for children 2, 4, and 6 months of age or diphtheria-tetanus-acellular pertussis vaccine (Infanrix, GlaxoSmithKline) for children 18 months of age, using 1 of 3 techniques: Australian (23 gauge, 25 mm long needle inserted at the …

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  • * Information provided by author.

  • For correspondence: Dr I F Cook, Princess Park Clinic, Sheppaton, Victoria, Australia. drifcook{at}

  • Source of funding: Hunter Division of General Practice (for statistical analysis).