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  • Multivitamin and multimineral supplements did not reduce reported infection days or related use of healthcare services in elderly people

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Multivitamin and multimineral supplements did not reduce reported infection days or related use of healthcare services in elderly people

https://doi.org/10.1136/ebn.9.1.25

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    Avenell A, Campbell MK, Cook JA, et al. Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): pragmatic, randomised, double blind, placebo controlled trial. BMJ 2005;331:324–9.OpenUrlAbstract/FREE Full Text

    Q Does supplementation with multivitamins and multiminerals reduce days of infection and related use of healthcare services and improve quality of life (QOL) in elderly people living in the community?

    METHODS

    Embedded ImageDesign:

    randomised placebo controlled trial.

    Embedded ImageAllocation:

    concealed.

    Embedded ImageBlinding:

    blinded (patients, healthcare providers, data collectors, outcome assessors, and data analysts).

    Embedded ImageFollow up period:

    1 year.

    Embedded ImageSetting:

    6 general practices in Grampian, UK.

    Embedded ImageParticipants:

    910 people ⩾65 years of age (53% men), who were registered with one of the general practices. Exclusion criteria were use of vitamin, mineral, or fish oil supplements in the previous 3 months (or previous month for water soluble vitamins); or vitamin B12 injection in the previous 3 months.

    Embedded ImageIntervention:

    1 daily tablet of a multivitamin and multimineral supplement (n = 456) or matching sorbitol placebo (n = 454) for 1 year. …

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    Footnotes

    • For correspondence: Dr A Avenell, Health Services Research Unit, School of Medicine, University of Aberdeen, Aberdeen, UK. a.avenell{at}abdn.ac.uk

    • Source of funding: Health Foundation (formerly PPP Healthcare Medical Trust).