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An educational booklet did not improve adherence or symptoms in patients prescribed thyroxine for primary hypothyroidism

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Q Does an educational booklet addressing lay health beliefs about medicine-taking improve adherence in patients prescribed thyroxine for primary hypothyroidism?


Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:

{not concealed}.*

Embedded ImageBlinding:

blinded (laboratory staff assessing thyroid stimulating hormone [TSH] assays).

Embedded ImageFollow up period:

median 96 days.

Embedded ImageSetting:

3 suburban general practices (18 physicians) in northwest England, UK.

Embedded ImagePatients:

332 patients ⩾18 years of age (mean age 62 y, 92% women) who were taking a stable dose of thyroxine (ie, dose unchanged over the previous 8 wks) for primary hypothyroidism caused by thyroidectomy, radio-iodine treatment, or autoimmune thyroiditis. Patients with serious illness were …

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  • * Information provided by author.


  • * Information provided by author.

  • For correspondence: Dr M Crilly, Department of Public Health, University of Aberdeen Medical School, Aberdeen, UK. mike.crilly{at}

  • Source of funding: British Medical Association.