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Glargine dose titration by patients and by physicians were equally effective for preventing severe hypoglycaemia

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Q In patients with suboptimally controlled type 2 diabetes mellitus, is insulin glargine dose titration by a physician equivalent to titration by the patient for preventing severe hypoglycaemia and improving glycaemic control?


Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:

unclear concealment.

Embedded ImageBlinding:


Embedded ImageFollow up period:

24 weeks.

Embedded ImageSetting:

611 centres in 59 countries in western and eastern Europe, South America, Asia, and Africa/Middle East.

Embedded ImagePatients:

5033 patients ⩾18 years of age (mean age 58 y, 52% women) who had suboptimally controlled type 2 diabetes mellitus (ie, …

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  • For correspondence: Dr M Davies, University Hospitals of Leicester, Leicester, UK. melanie.davies{at}

  • Source of funding: Sanofi-Aventis.