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After 3 months, low dose oral contraceptives reduced pain in adolescent girls with moderate to severe dysmenorrhoea

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Q What is the efficacy of low dose oral contraceptives (OCs) for primary dysmenorrhoea in adolescent girls?


Embedded ImageDesign:

randomised placebo controlled trial.

Embedded ImageAllocation:

unclear concealment.

Embedded ImageBlinding:

blinded (patients and healthcare providers).

Embedded ImageFollow up period:

3 months.

Embedded ImageSetting:

a single academic medical centre in New York, USA.

Embedded ImagePatients:

76 healthy adolescent girls ⩽19 years of age (mean age 17 y) who had dysmenorrhoea that was classified using the Robinson modification of the Andersch scale as moderate (sometimes or always experiencing very painful menstrual cramps) or severe (sometimes or always cutting back on activities in addition to experiencing painful menstrual cramps); regular menstrual cycles for ⩾1 year; menstrual cycle length of 21–35 days; and were abstinent or used condoms. Exclusion criteria were need for …

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  • For correspondence: Dr A R Davis, Columbia University Medical Center, New York, NY, USA. ard4{at}

  • Source of funding: National Institute of Child Health and Human Development; Wyeth Pharmaceuticals provided oral contraceptive and placebo pills.