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Topical chloramphenicol was not effective for acute infective conjunctivitis in children

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Q In children with acute infective conjunctivitis, is topical chloramphenicol effective for inducing clinical cure?


Embedded ImageDesign:

randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (patients, healthcare providers, data collectors, outcome assessors, and data analysts).

Embedded ImageFollow up period:

7 days for the primary outcome plus an extra 5 weeks to assess relapse.

Embedded ImageSetting:

12 primary practices in Oxfordshire, UK.

Embedded ImagePatients:

326 children 6 months to 12 years of age (mean age 3 y, 53% boys) who had acute infective conjunctivitis. Exclusion criteria included allergy to chloramphenicol, use of antibiotics (current or within the previous 48 h), evidence of severe infection, and children …

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  • For correspondence: Dr P W Rose, Department of Primary Health Care, University of Oxford, Oxford, UK. peter.rose{at}

  • Source of funding: Medical Research Council.