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Treatment
Topical chloramphenicol was not effective for acute infective conjunctivitis in children

https://doi.org/10.1136/ebn.9.1.12

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    Rose PW, Harnden A, Brueggemann AB, et al. Chloramphenicol treatment for acute infective conjunctivitis in children in primary care: a randomised double-blind placebo-controlled trial. Lancet 2005;366:37–43.OpenUrlCrossRefPubMedWeb of Science

    Q In children with acute infective conjunctivitis, is topical chloramphenicol effective for inducing clinical cure?

    METHODS

    Embedded ImageDesign:

    randomised controlled trial.

    Embedded ImageAllocation:

    concealed.

    Embedded ImageBlinding:

    blinded (patients, healthcare providers, data collectors, outcome assessors, and data analysts).

    Embedded ImageFollow up period:

    7 days for the primary outcome plus an extra 5 weeks to assess relapse.

    Embedded ImageSetting:

    12 primary practices in Oxfordshire, UK.

    Embedded ImagePatients:

    326 children 6 months to 12 years of age (mean age 3 y, 53% boys) who had acute infective conjunctivitis. Exclusion criteria included allergy to chloramphenicol, use of antibiotics (current or within the previous 48 h), evidence of severe infection, and children …

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    Footnotes

    • For correspondence: Dr P W Rose, Department of Primary Health Care, University of Oxford, Oxford, UK. peter.rose{at}dphpc.ox.ac.uk

    • Source of funding: Medical Research Council.