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Liposomal lidocaine improved intravenous cannulation success rates in children

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Q In children, does use of liposomal lidocaine before intravenous (IV) cannulation improve cannulation success rates and reduce pain, procedure duration, and adverse skin reactions more than placebo?


Embedded ImageDesign:

randomised placebo controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (patients and healthcare providers).

Embedded ImageFollow up period:

immediately after first cannulation attempt.

Embedded ImageSetting:

emergency department of a children’s hospital in Toronto, Ontario, Canada.

Embedded ImagePatients:

151 children who were 1 month to 17 years of age and required a peripheral IV cannula. Exclusion criteria were critical illness requiring immediate cannulation (eg, sepsis or severe dehydration), known or suspected hypersensitivity to local anaesthetics, current administration of opioid or topical anaesthesia, or previous participation.

Embedded ImageIntervention:

4% liposomal lidocaine cream, 1 g, (n = 76) or placebo …

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  • For correspondence: Dr A Taddio, Department of Pharmacy, Hospital for Sick Children, Toronto, Ontario, Canada. anna.taddio{at}

  • Sources of funding: RGR Pharma; Ferndale Laboratories provided liposomal lidocaine and placebo creams.