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Treatment
Aspirin, 1000 mg, reduced moderate to severe pain in acute migraine headache

https://doi.org/10.1136/ebn.8.4.107

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    Lipton RB, Goldstein J, Baggish JS, et al. Aspirin is efficacious for the treatment of acute migraine. Headache 2005;45:283–92.OpenUrlCrossRefPubMedWeb of Science

    Q Is a single dose of aspirin, 1000 mg, effective for treatment of acute migraine with moderate to severe pain intensity?

    METHODS

    Embedded ImageDesign:

    Randomised, placebo controlled trial.

    Embedded ImageAllocation:

    unclear concealment.

    Embedded ImageBlinding:

    blinded (patients).

    Embedded ImageFollow up period:

    several time points up to 24 hours.

    Embedded ImageSetting:

    USA.

    Embedded ImagePatients:

    485 patients who were 18–50 years of age (mean age 37 y, 79% women, 77% white); had experienced migraine headache, with or without aura, according to International Headache Society (IHS) criteria; had at least moderate pain; and had ⩾1 but ⩽6 migraines per month during the previous year. Exclusion criteria included vomiting ⩾20% of the time during an attack; initiation of preventive medication in the past 3 months or use of alkaloids to treat migraine; use of anticoagulant, gout, or arthritis medications; and previous non-responsiveness …

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    Footnotes

    • For correspondence: Dr R B Lipton, Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA. rliptonaecom.yu.edu

    • Source of funding: Bayer Corporation, Morristown, NJ, USA.