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Q Does mild induced hypothermia reduce mortality and improve long term function in patients with moderate to severe head injury?
Medline, EMBASE/Excerpta Medica, Cochrane Injuries Group Specialised Register, Cochrane Controlled Trials Register (all to 2001); hand searches of conference proceedings and reference lists of relevant trials and review articles; and investigators in the field.
Study selection and assessment:
randomised controlled trials (RCTs) that compared mild therapeutic hypothermia (local or systemic therapeutic cooling [using a fluid filled cooling blanket, a “Bear Hugger” air cooling device, ice water lavage, or combination, or other method] to a target temperature ⩽34–35°C for ⩾12 hours beginning on admission to the intensive care unit or when intracranial pressure [ICP] became uncontrollable by conventional management) with control (open or normothermia) in patients with any closed head injury requiring hospital …
For correspondence: Dr P Alderson, National Institute for Clinical Excellence, London, UK.
Source of funding: no external funding.