Article Text

Download PDFPDF
Review: mild induced hypothermia does not reduce mortality or severe disability in moderate to severe head injury

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Q Does mild induced hypothermia reduce mortality and improve long term function in patients with moderate to severe head injury?


Embedded ImageData sources:

Medline, EMBASE/Excerpta Medica, Cochrane Injuries Group Specialised Register, Cochrane Controlled Trials Register (all to 2001); hand searches of conference proceedings and reference lists of relevant trials and review articles; and investigators in the field.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs) that compared mild therapeutic hypothermia (local or systemic therapeutic cooling [using a fluid filled cooling blanket, a “Bear Hugger” air cooling device, ice water lavage, or combination, or other method] to a target temperature ⩽34–35°C for ⩾12 hours beginning on admission to the intensive care unit or when intracranial pressure [ICP] became uncontrollable by conventional management) with control (open or normothermia) in patients with any closed head injury requiring hospital …

View Full Text


  • For correspondence: Dr P Alderson, National Institute for Clinical Excellence, London, UK.

  • Source of funding: no external funding.