You are here

Article Text

Article menu
Download PDFPDF
Treatment
Review: high dose vitamin E supplementation is associated with increased all cause mortality

https://doi.org/10.1136/ebn.8.3.82

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Miller ER 3rd, Pastor-Barriuso R, Dalal D, et al. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005;142:37–46.OpenUrlCrossRefPubMedWeb of Science

    Q Does vitamin E supplementation increase all cause mortality? Does a dose-response relation exist between vitamin E and all cause mortality?

    METHODS

    Embedded ImageData sources:

    Medline (1966 to August 2004), Cochrane Central Register of Controlled Trials, bibliographies of relevant studies and reviews, and personal files of the investigators.

    Embedded ImageStudy selection and assessment:

    randomised controlled trials (RCTs) that compared vitamin E supplementation (alone or combined with other vitamins or minerals) with a control or placebo group in men or non-pregnant women, study duration and follow up were >1 year, and ⩾10 deaths occurred.

    Embedded ImageOutcomes:

    all cause mortality.

    MAIN RESULTS

    19 RCTs (n = 135 967, mean age range 47–84 y) met the selection …

    View Full Text

    Footnotes

    • For correspondence: Dr E R Miller 3rd, Johns Hopkins Medical Institutions, Baltimore, MD, USA. ermillerjhmi.edu

    • Sources of funding: in part, Instituto de Salud Carlos III.