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Medline (1966 to August 2004), Cochrane Central Register of Controlled Trials, bibliographies of relevant studies and reviews, and personal files of the investigators.
Study selection and assessment:
randomised controlled trials (RCTs) that compared vitamin E supplementation (alone or combined with other vitamins or minerals) with a control or placebo group in men or non-pregnant women, study duration and follow up were >1 year, and ⩾10 deaths occurred.
all cause mortality.
19 RCTs (n = 135 967, mean age range 47–84 y) met the selection …
For correspondence: Dr E R Miller 3rd, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Sources of funding: in part, Instituto de Salud Carlos III.