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randomised placebo controlled trial (Corticosteroid Randomisation After Significant Head injury [CRASH]).
blinded (clinicians and patients).
Follow up period:
239 hospitals in 49 countries.
10 008 patients who were ⩾16 years of age (mean age 37 y, 81% men) and had sustained a head injury within 8 hours, had a Glasgow Coma Score (GCS) ⩽14, and whose treating physician was uncertain whether to treat with corticosteroids.
a loading dose of methylprednisolone, 2 g over 1 hour in a 100 ml infusion, followed up by a maintenance …
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