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randomised placebo controlled trial.
blinded (patients and healthcare providers).
Follow up period:
multiple centres in the US.
387 women ⩾18 years of age (mean age 34 y, 67% white) who had active, acute candida vaginitis (severity score ⩾3), a positive result on microscopic examination of vaginal secretions, ⩾4 episodes of candida vaginitis in the previous 12 months, and were clinically cured (severity score <3) at 14 days after receiving 3 sequential doses of fluconazole, 150 mg, at 72 hour intervals. Exclusion criteria: lack of confirmation of microscopic findings by culture, pregnancy, mixed infections or known seropositivity for HIV, or use of antifungal agents in the previous 4 weeks.
a single oral dose of fluconazole, …
↵* Data on allocation status only available for 343 women included in the efficacy analysis.
↵* Calculated from data in original article.
For correspondence: Dr J D Sobel, Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI, USA.
Source of funding: Pfizer Pharmaceutical.