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Treatment
Review: antioxidant supplementation does not reduce gastrointestinal cancer

https://doi.org/10.1136/ebn.8.2.48

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    Bjelakovic G, Nikolova D, Simonetti RG, et al. Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet 2004;364:1219–28. Bjelakovic G, Nikolova D, Simonetti R, et al. Antioxidant supplements for preventing gastrointestinal cancers. Cochrane Database Syst Rev 2004;(4):CD004183.

    Q Do antioxidant supplements reduce the risk of gastrointestinal cancer?

    METHODS

    Embedded ImageData sources:

    Cochrane controlled trial registers for 4 gastrointestinal disease groups, Cochrane Central Register of Controlled Trials (2003, Issue 1), Medline (1966 to February 2003), EMBASE/Excerpta Medica (1985 to February 2003), LILACS (1982 to February 2003), Science Citation Index Expanded (1945 to February 2003), Chinese Biomedical Database (1978 to March 2003), reference lists of retrieved studies, and manufacturers of antioxidant supplements.

    Embedded ImageStudy selection and assessment:

    randomised controlled trials (RCTs) comparing antioxidant supplementation (β carotene; vitamins A, C, and E; and selenium, separately or in combination) with placebo in patients mainly with non-gastrointestinal …

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    Footnotes

    • For correspondence: Dr G Bjelakovic, Department of Internal Medicine—Gastroenterology and Hepatology, Medical Faculty, University of Nis, Serbia and Montenegro. goranbjunis.ni.ac.yu

    • Sources of funding: Knowledge and Research Centre for Alternative Medicine (ViFAB) and Copenhagen Trial Unit.