Article Text
Statistics from Altmetric.com
Q Is vaccination effective for reducing the incidence of influenza in healthy people 14–60 years of age?
METHODS
Data sources:
Cochrane Central Register of Controlled Trials (Cochrane Library, Issue 1, 2004), MEDLINE (1966–2003), EMBASE/Excerpta Medica (1990–2003), bibliographies of relevant articles, and manufacturers and researchers.
Study selection and assessment:
controlled trials (published in any language) that evaluated the effectiveness of influenza vaccines for protection from exposure to naturally occurring influenza in healthy people 14–60 years of age.
Outcomes:
incidence of clinically defined influenza (CDI) (unspecified or specified on the basis of specific symptoms or signs) and serologically confirmed influenza (SCI).
MAIN RESULTS
47 trials (25 randomised controlled trials [RCTs], n = 59 566) met the selection criteria. (1) Influenza vaccine (inactivated parenteral vaccine [IP], live aerosol …
Footnotes
For correspondence: Dr V Demicheli, Servizo Sovrazonale di Epidemiologia, Piemonte, Italy. demichelivittorioasl20.piemonte.it
Source of funding: Ministry of Defence, UK.