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Review: vaccination reduces the incidence of serologically confirmed influenza in healthy adults

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Q Is vaccination effective for reducing the incidence of influenza in healthy people 14–60 years of age?


Embedded ImageData sources:

Cochrane Central Register of Controlled Trials (Cochrane Library, Issue 1, 2004), MEDLINE (1966–2003), EMBASE/Excerpta Medica (1990–2003), bibliographies of relevant articles, and manufacturers and researchers.

Embedded ImageStudy selection and assessment:

controlled trials (published in any language) that evaluated the effectiveness of influenza vaccines for protection from exposure to naturally occurring influenza in healthy people 14–60 years of age.

Embedded ImageOutcomes:

incidence of clinically defined influenza (CDI) (unspecified or specified on the basis of specific symptoms or signs) and serologically confirmed influenza (SCI).


47 trials (25 randomised controlled trials [RCTs], n = 59 566) met the selection criteria. (1) Influenza vaccine (inactivated parenteral vaccine [IP], live aerosol …

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  • For correspondence: Dr V Demicheli, Servizo Sovrazonale di Epidemiologia, Piemonte, Italy.

  • Source of funding: Ministry of Defence, UK.